The polysaccharides from Yiqi Yangyin complex attenuated mammary gland hyperplasia: Integrating underlying biological mechanisms and network pharmacology

Yiqi Yangyin complex (YYC), the homology of medicine and food, is comprised Polygonati Rhizoma, Lycii Fructus, Codonopsis Pilosula, Rehmanniae Radix. Herein, YYC polysaccharide treatment effectively attenuated progression MGH in a mice model-induced with estrogen progestogen. significantly relived hormonal disorders by reducing levels receptor α (ERα) progesterone (PR), substantially elevated protein level BCL2-associated X (Bax) down-regulated expression B-cell lymphoma-2 (BCL-2). Finally, key targets ERα, PR, Bax BCL-2 were predicted enriched on signaling pathway apoptosis network pharmacology. This finding suggests that may influence sex hormones through then induce to balance normal functions mammary gland. study thus provided evidences for potential therapeutic efficacy revealed correlated regulatory pathways.